MRI studies by Paul Thompson PhD, UCLA Professor of Neurology, revealed that brains of overweight individuals showed 4 percent less brain tissue, while obese brains had 8 percent less tissue than those of normal-weight people. The brains of overweight persons looked 8 years older and those of obese individuals looked 16 years older than those of normal-weight people. Obesity is linked with more than 50 diseases—including type 2 diabetes, high blood pressure, cardiovascular disease, cancer and cancer reoccurrence, and dementia. Obesity may even be worse for females. Women who are obese throughout life are at increased risk for developing dementia, perhaps due to increased secretion of cortisol.