People
sometimes ask if it’s worth it to do the work necessary for recovery from
identified childhood trauma. Corticotropin Releasing Factor or CRF is a
very powerful brain substance. Effects of CRF in limbic brain regions have been
associated with increased fear, alertness, decreased appetite and libido, all
functions relevant in the Fight-or-flight response and dysregulated in
depression and anxiety disorders. Over-activity of the CRF/CRF1
receptor system has been demonstrated to be one of the long term
neurobiological sequelae of early life
trauma, a major risk factor for the development of affective disorders
(such as depession). In fact, both rodents and non-human primates exposed to
adverse experiences in early life exhibit evidence of hyperactivity of the CRF
system as adults. Recovery work may be able to dampen down some of this CRF
hyperactivity.
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