Sunday, July 22, 2012

Dendrimers, BBB, and CP

Have you heard about dendrimers? These synthetic, snowflake-shaped molecules were invented in 1979 by Don Tomalia, director of the National Dendrimer Nanotechnology Center in Mt. Pleasant, Michigan. Researchers at Johns Hopkins University School of Medicine recently affixed an anti-inflammatory drug to dendrimers and injected the combination into the blood stream of newborn rabbits that showed symptoms similar to those exhibited by children with cerebral palsy. The dendrimers transported the drug across the Blood Brain Barrier and targeted microglia and astrocytes. This stopped further inflammation and improved motor function. Potentially, this could be very good news for individuals with cerebral-palsy symptoms.

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