Deaths from caffeine intoxication are uncommon, and they do occur. The first paper about lethal caffeine intoxication was published by Jokela et al. in 1959 [1], and it described the accidental death of a young woman following intravenous administration of caffeine. Studies by NIH reported 92 deaths that had been identified. They are more likely to occur in psychiatric patients, athletes, and infants. Common features of caffeine intoxication from excessive caffeine consumption—“caffeinism”—include anxiety, agitation, restlessness, insomnia, gastrointestinal disturbances, tremors, psychomotor agitation, and, in some cases, death. Studies in Australia recommended that pregnant women avoid caffeine or limit their total intake to less than 200 mg per day. High caffeine levels may increase the risk for miscarriage, a difficult birth process, and/or having a baby with a low birth weight.
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