Tuesday, February 9, 2016

Trauma and CRF

People sometimes ask if it’s worth it to do the work necessary for recovery from identified childhood trauma. Corticotropin Releasing Factor or CRF is a very powerful brain substance. Effects of CRF in limbic brain regions have been associated with increased fear, alertness, decreased appetite and libido, all functions relevant in the Fight-or-flight response and dysregulated in depression and anxiety disorders. Over-activity of the CRF/CRF1 receptor system has been demonstrated to be one of the long term neurobiological sequelae of early life trauma, a major risk factor for the development of affective disorders (such as depession). In fact, both rodents and non-human primates exposed to adverse experiences in early life exhibit evidence of hyperactivity of the CRF system as adults. Recovery work may be able to dampen down some of this CRF hyperactivity.


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