According to Matthias Nahrendorf, M.D., Ph.D., professor at Harvard Medical School and
Massachusetts General Hospital in Boston, tiny tunnels run from skull bone
marrow to the lining of the brain and may provide a direct route for immune
cells responding to injuries caused by stroke and other brain disorders. This is a previously
unknown shortcut that immune system cells can use on their way from skull marrow
cavities towards the central nervous system. Rather than traveling through the
general blood circulation, white blood cells produced in skull bone marrow
migrate through channels that directly connect the skull marrow with meninges,
the three protective layers that wrap around the brain. These channels exist in
mice brains and in human brains.
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