It should come as no surprise to realize that there is a direct relationship between
emotional stress and physical distress. Another mechanism that lends credence
to physiology as the source of intestinal dysfunctions is the system of mast
cells in the gut that have an important role in immune response. During stress,
trauma, or fight or flight reactions, brain neurons call for more immune
surveillance, and mast cells in the wall of the GI system are activated. These
mast cells release histamines and other inflammatory agents, mobilizing the
enteric nervous system to expel the perceived intruders, which can cause
diarrhea. According to Dr. Mawe, professor of anatomy and neurobiology at the
University of Vermont, In
animals, inflammation
makes the sensory neurons in the gut fire more often, causing a kind of sensory
hyperactivity. He is reported to have said, “I have a theory that some chronic
disorders may be caused by something like attention deficit disorder in the
gut.”
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