DNA
and its associated material replicate at regular intervals, a process essential
to all living organisms. This process contributes to everything from how the
body responds to disease to hair color. DNA replication was identified in the
late 1950s, but understanding exactly how this process of replication occurs
and how it is regulated has been elusive. A team of researchers at Florida
State University appear to have unlocked a decades-old mystery about how a
critical cellular process is regulated and what that could mean for the future
study of genetics. David Gilbert and doctoral student Jiao Sima
published a paper in the journal Cell in December that reported on experiments showing
there are specific points along the DNA molecule that control replication.
Examining a single segment of DNA in the highest possible 3-D resolution, they
identified three sequences along the DNA molecule touching each other
frequently. They found that these three elements together were the key to DNA
replication.
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