According to the authors of Ghosts from the Nursery, excessive shame
results in hypoarousal of the brain, the opposite of excitement and
playfulness. This can impact the development of empathy. If the synapses in the
brain are never built in childhood due to neglect, or if they are destroyed by
neurochemicals resulting from chronic stress, the individual may be left with
the ability to connect, trust, or experience empathy. Extreme instances may
result in the development of sociopathy. This was enlarged upon by the authors
of Liars, Lovers, and Heroes, who
estimated that sociopaths form about 20% of the prison population while only
represented in a small fraction of the general population. Many of these
individuals appear insensitive to the threat of punishment. Also, many were
abused as children and never learned to empathize with the pain and suffering
of others. Brain scans showed an 11% reduction in gray matter volume in the
prefrontal area of the brain (compared with a control group).
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