Prenatal stress can have a lasting detrimental impact on
psychological health. In a recent study investigating correlations among
maternal in pregnancy and methylation in teenagers and their mothers, it has
been found that children of women who were abused during pregnancy were
significantly more likely than others to have methylated
glucocorticoid-receptor genes, which in turn change the response to stress, leading
to a higher susceptibility to anxiety. As these sustained epigenetic modifications are
established in utero, the researchers consider this to be a plausible mechanism by
which prenatal stress may program adult psychosocial function. Prenatal stress is
known to alter the hypothalamic-pituitary-adrenal (HPA)-axis regulatory
function later in life. Specifically gestational marital discord is associated
with psychopathology of the offspring.
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