In 2014, the National Institutes of Health established guidelines for preclinical experimental design. These guidelines were designed to encourage researchers to adopt best practices, such as randomization and the inclusion of both male and female lab animals. Many thought this might result in a more radical change in favor of equal research on males and females. A report in May of 2017 showed that the best-practice guidelines were not widely being adhered to. Researchers reviewed 4,000 papers published from 2006 to 2016 in five journals under the umbrella of the American Heart Association: Circulation, Circulation Research, Hypertension, Stroke, and Arteriosclerosis, Thrombosis, and Vascular Biology. They were comparing the preclinical design against four criteria related to the MIH guidelines of 2014. The analysis showed that male animals were still being used about the same in pre-clinical trials or were increasing. Of the five journals reviewed, Stroke provided the best record of compliance. I am hopeful that is a start.