Charcot-Marie-Tooth
disease tends to affect peripheral nerves. These nerves are outside the brain
and spinal cord (the central nervous system) and enervate the sensory organs
and muscles in the arms and legs. CMT is caused by
mutations in genes that produce proteins involved in the structure and function
of either the peripheral nerve axon or the myelin sheath. In order to speed the
transmission of messages and to prevent loss of electrical signals, Myelin
surrounds the nerve axon like a jelly-roll cake. There are dozens of types of
CMT. Some forms require only one copy of the mutated gene from one parent; some
need a mutated gene from both parents; and some are linked to the X chromosome.
Following are some resources for additional information.
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