Glymphatic System & Beta-Amyloid

Dr. Nedergaard and her colleagues, discovered that the glymphatic system can help remove the toxic protein known as beta-amyloid from brain tissue. Beta-amyloid is well known for accumulating in the brains of patients with Alzheimer's disease. Other research has shown that brain levels of beta-amyloid decrease during sleep. In their new study, the team tested the idea that sleep might affect beta-amyloid clearance by regulating the glymphatic system. Indeed, there appears to be a link between the amount of sleep the brain receives, and the effectiveness of the glymphatic system’s ability to clear beta-amyloid from brain tissue. The study was funded by NIH’s National Institute of Neurological Disorders and Stroke (NINDS).

 

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